Police were called to Chestnut Hill Hospital on the 8800 block of Germantown Avenue just before 9 p.m.
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They learned that a 17-year-old girl had been brought to the hospital by a private vehicle.
The girl was shot four times, including once in the head.
She was pronounced dead a short time later, officials say.
Police later learned the incident happened on the 6600 block of Ross Street while the victim was sitting in the passenger seat of a white Toyota with three other people.
That's when a dark-colored SUV drove up to the parked Toyota, and someone fired at the people inside, striking the teen.
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Authorities say she was caught in the crossfire and was not the intended target.
The incident is also believed to have been caught on video.
So far, no arrests have been made at this time.
Anyone with information is asked to contact police.