Detectives are investigating at least 18 shootings, six homicides and eight stabbings since Saturday morning.
The gun violence occurred from South Philadelphia to Logan, and brought the city's death toll to more than 180 for the year.
While that is down from last year's record pace, it is worse than any other in the past 15 years.
Police were called to 57th and Hadfield streets in West Philadelphia for the latest weekend shooting around 9:40 p.m. Sunday.
The 24-year-old male victim was shot six times, police say.
He was taken to the hospital in stable condition.
Authorities say the victim of a fatal shooting hours earlier was an Uber driver.
It happened just after 5 p.m. Sunday on the 5800 block of North 16th Street in the city's Logan neighborhood.
Police say the male victim, believed to be in his late teens to early 20s, was shot in the head. He was rushed to an area hospital where he was later pronounced dead.
Nearly 12 hours earlier, a 29-year-old man was shot and killed on the 4900 block of Aspen Street in West Philadelphia, authorities said.
Neighbors watched from behind police tape as investigators laid down evidence markers on North 11th Street and Rising Sun Avenue around 5:45 a.m. Sunday.
Police were called to the scene after a man was found shot twice in the chest. Medics pronounced him dead on the scene.
"He was a really nice guy. We always loved him around here. He never messed with nobody. He had a real beautiful heart," said a neighbor who didn't want to be identified.
The neighbor said the victim was the neighborhood mechanic who helped everyone with their cars.
Police: 12 shot and 4 dead after a string of shootings in Philadelphia
At 4 a.m. Sunday, investigators were called to the 2100 block of Diamond Street where police say a man shot a 38-year-old would-be robber who pointed a gun at him after leaving a corner store. The robber died at Temple Hospital.
At 2 a.m. Sunday, police found a man lying on the street with gunshot wounds on the 5500 block of Hill Creek Circle.
Just before 11 p.m. Saturday, a 33-year-old man died after being shot at least 10 times in the chest on 72nd Avenue in West Oak Lane.
"What I'm thinking is it's very sad all the senseless murders and killings out here in these streets," said Rodney Williams of North Philadelphia.
In addition to the deadly violence, three teenagers were shot earlier Saturday night at Penns Landing.
Police say that the shooting happened around 9:30 p.m. and all of the victims are 14-years-old, two girls and one boy.
Anyone with information on any of these shootings is asked to call police at 215-686-TIPS.