Gunshots rang out around 4:19 p.m. on the 3800 block of Folsom Street in the city's Mantua section.
Police say a 21-year-old man was shot multiple times. He's currently listed in critical condition at an area hospital.
Two hours later, in the city's Logan section, police say a 22-year-old man and an 18-year-old man were both shot on the 5100 block of 8th Street in the city's Logan neighborhood.
22-year-old man, 18-year-old man shot in Philadelphia's Logan section
The 22-year-old victim is currently listed in critical condition after being shot once in the head and thigh. The second victim is in stable condition, said police.
The gunfire continued in North Philadelphia where police say a 51-year-old man and a 31-year-old man were both shot around 6:30 p.m. Both men are listed in stable condition.
Police say also around 6 p.m., at least 9 shell casings were found at 63rd and Oxford streets in the city's Overbrook section, less than a block from where a 15-year-old was gunned down last weekend. No victims have been found but police are searching through video in hopes of finding the trigger puller.
READ MORE: City leaders react after dozens of people shot, several killed over holiday weekend in Philadelphia
Dozens shot, several killed during weekend violence in Philadelphia
Around 7:46 p.m., police say a 57-year-old man was shot in the arm on the 5900 block of Spring Street. He is expected to survive.
Nearly hour later, police say a 25-year-old man was shot three times on the 1600 block of N. 6th Street. He is also expected to survive.
No arrests have been made in connection with these shootings. Anyone with any information is asked to call police at 215-686-TIPS.
According to 6abc's data journalism team, for the first five days of July, at least 45 people were shot in the city. Through July 5 of this year, at least 871 people have been shot in the city. That's a 24% increase from the year before.
Philadelphia Police Commissioner Danielle Outlaw said there is a larger strategy to combat gun violence with several facets including reassessing how police respond to calls about addiction and homelessness.
She added they are targeting neighborhoods where violence persists and are working closely with other law enforcement agencies, including federal counterparts.
As far as defunding police, she said, "While I do think there are a lot of things the police haven't been responding to, and more money needs to be bolstered around social services, taking money away at these large levels from the police department - I don't think is the way to go."
Outlaw added that community involvement and the police department's relationship with the community is vital.
"None of this will be successful without the inclusion of our community stakeholders. That's important. We know we can't arrest our way out of situations," she said.