Chopper 6 was over the scene, where a large plume of thick, black smoke could be seen for miles.
Huge plume of smoke amid large junkyard fire in Delco
The fire appears to be at a junkyard on Industrial Drive in Delaware County.
Firefighters could be seen trying to douse the flames with water.
Residents in the area should take precautions to avoid unnecessary exposure to smoke.
The Health Department recommends avoiding going outdoors as much as possible, as well as keeping all windows and doors closed to minimize air pollution in your home.
Health officials also say you should recirculate air with fans to avoid bringing more air pollution into your home.
It is unclear at this time what is burning.
Many might already be staying inside and avoiding the outdoors as Philadelphia heats up for its 5th heat wave of the year, with temps expected to hit the triple digits Wednesday.
Extreme heat in store for Philadelphia area on Wednesday
This also comes as the Northeast is already expecting millions to be exposed to dangerous smoke amid several large wildfires blazing in Canada and Minnesota.
Wildfires expose millions in the Midwest and Northeast US to dangerous smoke
By Wednesday afternoon, intense smoke from the wildfires will spread into the East Coast and Midwest, including parts of the New England coast, northern Pennsylvania, Detroit and Milwaukee, according to Tyler Hasenstein, meteorologist with the National Weather Service in Chanhassen, Minnesota.
There is also a Code Orange Air Quality Alert Wendesday in New Jersey and Delaware due to unhealthy levels from the ozone.
Code Orange Air Quality Alert in NJ, Del.
This is a developing story and will be updated.