West Philadelphia's own Quinta Brunson handed Staley, who is the coach of the national champion South Carolina women's basketball team, the Jimmy V Award.
Staley was honored for both her support and fight for equality for women's sports, and for her leadership in the fight against cancer.
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Her friend, Tennessee standout Nicki McCray-Penson, died of breast cancer and Staley's sister was diagnosed with leukemia.
Staley's Gamecocks won the ESPY's best team award.
Simone Biles and Caitlin Clark also took home trophies from the award show hosted by Serena Williams.