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Officials say the drug is being mixed into fentanyl and other illicit opioids, contributing to a growing number of overdose deaths.
Xylazine is a sedative used by veterinarians and would still be available for its intended use under the new bill.
RELATED: Pennsylvania taking steps to control access to xylazine, a drug also known as tranq
Under the bill, xylazine would be listed as a Schedule III drug, which is a controlled substance subject to various rules.
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Both the Pennsylvania House of Representatives and the Senate approved the bill in the past week.
RELATED: Emerging drug 'Tranq' leading to amputations among users
Action News Special Report: Emerging drug 'Tranq' leading to amputations