Amanda DeGuio went missing in June 2014 after returning from a trip to Florida.
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She left home without her cell phone, credit cards, or additional clothing, officials said.
"We continued to follow up on every tip we receive and investigate all possible leads," said Upper Darby Police Superintendent Tim Bernhardt. "This is an active investigation."
On Wednesday, local and federal authorities searched the backyard of a home on the 200 block of Red Pump Road in Nottingham.
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"With the amount of agencies involved in this case, it's been 8.5 years. This by far is the biggest visible presence throughout this investigation," said Kevin Ryan, the family's private investigator.
Deguio's mother and sister were at the scene. All of them hoped for closure, but now they're left with more questions as Amanda's body wasn't found at the property.
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"They're very strong. They've always been strong with this, but today it brings a whole new sense of feelings, nervousness," said Ryan. "Once we pulled up, I think reality set in for everybody including myself."
Action News has learned that the property that was searched belongs to a close friend of the family.
Investigators urge anyone with information on her disappearance to please come forward.