Separated by plexiglass and 12 feet of space, Harris and Pence argued the merits of their respective party's candidates for President, Democrat Joe Biden and incumbent Republican Donald Trump.
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The COVID-19 pandemic was arguably the topic of the night, setting off a fiery exchange between the two just moments into the debate.
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Trump tested positve for COVID-19 last week along with a number of other White House staffers and three GOP senators, leading many to question the Trump admin's response to the pandemic.
So how did the candidates do?
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