It happened just after 5 a.m. Tuesday on the 900 block of West County Line Road in Horsham.
The crash involved a tractor-trailer and a sedan.
Chopper 6 over the scene showed the sedan severely mangled.
According to police, the 19-year-old, who was driving the sedan, was rescued from the wreck but later died.
The road was closed until about 12:30 p.m.
Anyone who may have witnessed the crash is asked to call police.