Officers responded around 8:50 p.m. Tuesday to the 600 block of East 10th Street.
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The car, which had multiple bullet holes, crashed into a pole.
Police found one victim shot in the head and another with a graze wound.
They say a trail of blood from the car led officers to a third victim several blocks away from the crash.
Police said Wednesday that they believe the shooting occurred in the 2600 block of Northeast Boulevard.
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Witnesses tell police they saw a black car leaving the scene.
Police said the three victims were being treated at an area hospital.
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