The blaze sparked at a home on the 600 block of Randolph Street at about 4:30 a.m., officials said.
The victim, identified as 41-year-old Otoniel Fernandez, was pulled from the burning house, but could not be saved.
Three cats also died in the blaze.
Multiple fire marshals and a arson K9 were called to the scene to investigate. A cause has yet to be determined.
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