Police said the crash happened at about 5:30 p.m. in the 2100 block of East Westmoreland Street in the city's Port Richmond section.
According to investigators, someone sped away after hitting a man and a woman who were standing in the street.
The man is now in critical condition and the woman is stable.
Police said they are looking for a white Nissan sedan with front-end damage in connection with the crash.
Anyone with information is asked to call police.
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