Jayana Tanae Webb, 21, is charged with third-degree murder, homicide by vehicle while DUI, homicide by vehicle, manslaughter of a law enforcement officer in the second degree, driving under the influence and other charges.
State police said Webb was arraigned late Tuesday night and is being held without bail.
Cameras surrounded Webb as she made her way to a police cruiser on Tuesday morning.
The deadly crash occurred shortly before 1 a.m. Monday on I-95 southbound in the area of milepost 18 near the Stadium Complex, just north of Broad Street.
According to state police, the troopers were responding to reports of a man walking along I-95 south.
Suspect in custody after troopers, pedestrian killed on I-95
Authorities said the troopers were helping the pedestrian, who has since been identified as Reyes Rivera Oliveras, 28, of Allentown, into the back of their cruiser. Police said, at that time, Webb attempted to drive past the scene at a high rate of speed.
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State police said she fatally struck the two troopers and Oliveras, as well as the cruiser.
According to police, the impact was so great it threw the troopers into the northbound lanes of I-95.
2 troopers killed in crash on I-95 in South Philadelphia identified
Webb remained at the scene.
State police dispatch tried to contact the two state troopers, but when they did not get a response, they sent backup.
When backup arrived, police spotted witnesses attempting CPR on Mack and Sisca. The troopers, however, were pronounced dead at the scene.
"Our department is heartbroken with the tragedy that occurred early this morning in Philadelphia," PSP Commissioner Robert Evanchick said in a statement. "We ask our fellow Pennsylvanians to keep the families of our troopers and the pedestrian in their thoughts. This is an extremely difficult time."
The state troopers have been identified as 33-year-old Martin F. Mack III and 29-year-old Branden T. Sisca.
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Trooper Mack had been on the force since November 2014. Trooper Sisca had been on the force since February 2021. Both troopers spent their entire careers assigned to the Patrol Section of Troop K, Philadelphia.
Verified GoFundMe accounts have been set up to help the families of Trooper Mack and Trooper Sisca.
Webb was arraigned late Tuesday night and is currently being held without bail.
A preliminary hearing is scheduled for April 5.
Philadelphia District Attorney Larry Krasner said his office will seek to ensure Webb is held accountable for her alleged actions that resulted in this senseless loss of life.
"The deaths of Troopers Mack and Sisca, along with Mr. Oliveras, a civilian they were attempting to help to safety on I-95, are tragedies. I again extend my deepest condolences to the colleagues and loved ones of Troopers Mack and Sisca, as well as Mr. Oliveras," said Krasner in a statement.
WATCH: Police procession along I-95 after fatal crash
Police procession along I-95 after crash kills Pa. troopers, civilian