Laylo was visiting the city with his mother when a gunman opened fire while they were in an Uber headed to the airport.
It happened around 4 a.m. Saturday near 38th and Spruce streets.
Police say the gunman came up from behind and fired several rounds into the car. The gunman then pulled up on the driver's side of the car and fired additional gunshots.
Police sources say the shooter may have been in a black Cadillac.
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John was shot in the head and died from his injuries Sunday. His mother was injured by glass fragments.
"It's heartbreaking. It's very disturbing. This is the first time that we have a Filipino who is visiting the United States who would end up getting killed in the United States. So this doesn't happen every day," said Philippine Consul General Elmer Cato.
Sources tell Action News that investigators are reviewing video that may prove the shooter targeted the wrong car.
Mayor Kenney says they are working to return Laylo's remains to the Philippines as police continue to search for the gunman.
Anyone with information is asked to call police at 215-686-TIPS.