He had 12 points in 19 minutes after missing 11 games due to injuries sustained in the crash.
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Oubre spoke about the November 11 crash briefly earlier this week, saying, "I've spoken to police about this situation and they have an ongoing investigation. I've spoken to who I need to speak with about it and I'll keep it the way that it is."
No arrests have been made in the case.
Meanwhile, Joel Embiid scored a season-high 50 points and had 13 rebounds during Wednesday night's game.
Embiid reached 50 points for the sixth time in his career. He had a career-best 59 on Nov. 13, 2022, against Utah.
SEE ALSO: 76ers' Kelly Oubre speaks out for first time since injury from Center City hit-and-run
Kelly Oubre speaks about hit-and-run crash in Center City
The reigning NBA MVP was 19 of 24 from the field, making a 3-pointer on two attempts, and hit 11 of 13 free throws. He also had seven assists and six turnovers in just over 38 minutes.
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Tyrese Maxey added 26 points and also had seven assists. Jordan Poole led Washington with 23 points. The Wizards are 3-17.
Trailing 99-95, the Wizards opened the fourth quarter with a 5-0 run to retake the lead in a game that featured 22 changes and 13 ties. But after leading 102-101 with 8:48 remaining, the 76ers pushed the advantage to eight and held on.
Washington cut it to 122-119 on Poole's 3-pointer with 2:17 remaining, but it was the closest the Wizards would get.
Embiid was assessed a technical for slamming the ball down after being called for travelling with 2:36 remaining in the third as Washington extended its lead to 95-89. But Embiid's frustration was a spark, and Philadelphia ended the quarter on a 10-0 run.
Tyus Jones had 20 points for Washington, Daniel Gafford added 18 and Kyle Kuzma and Corey Kispert each had 16.
SEE ALSO: No video evidence of hit-and-run crash that injured 76ers' Kelly Oubre Jr., police say
No video evidence of hit-and-run crash that injured 76ers' Kelly Oubre Jr., police say
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UP NEXT
76ers: Host Atlanta on Friday night.
Wizards: At Brooklyn on Friday night.
The Associated Press contributed to this report.