The incident happened Wednesday just before 10:30 a.m. on the 2200 block of Cecil B. Moore Avenue.
Police say shots rang out, hitting the 64-year-old man in the head.
The victim was sitting inside of a brown Ford Expedition at the time of the shooting, according to officials.
The suspects were reportedly driving a dark-colored Ford SUV.
Police rushed the victim to Temple University Hospital, where he is listed in extremely critical condition.
No arrests have been made at this time.
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