It happened at the Superlodge Motel in the 1200 block of West Avenue in New Castle around 2:40 p.m. Sunday.
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Troopers found a 45-year-old man critically wounded outside the motel.
He was taken to the hospital where he later died of his injuries.
His identity has not been released.
State police are working to sort out what led to the stabbing.
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No arrests have been made.
Anyone with information is being asked to call police.
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