It happened just after 3 a.m. Saturday on the 700 block of West Russel Street.
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A 22-year-old man was shot in the abdomen and taken to Temple University Hospital where he died.
A man in his 40s remains in critical condition after he was shot in the neck.
A 54-year old woman was shot in the leg and is expected to recover.
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Police said an 18-year-old man later showed up at the hospital with a gunshot wound to the leg.
No arrests have been made.