It happened just before 4:30 a.m. Monday at the intersection of 63rd Street and Lindbergh Boulevard.
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Officials say two vehicles collided at that intersection then hit a third.
When crews arrived at the scene, they found some of the victims were trapped.
Everyone was removed from the wreckage.
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Police say most of the victims sustained head and neck injuries.
The 2-year-old child suffered bruises.
All six victims were taken to area hospitals in stable condition.
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