The crash happened just after 8 a.m. Tuesday on Torresdale Avenue at Knorr Street, not far from the Tacony Library.
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Surveillance video sent to Action News showed a pick-up truck run a red light and crash into the side of the bus.
The driver does not appear to stop. The truck also side-swipes several other cars after hitting the bus.
Chopper 6 over the scene showed the small school bus with front-end damage.
"I just heard the crash, came out and seen somebody had hit a bus. My dad went out there and made sure no kids were hurt," said James Osuch of Tacony. "From my experience, cars do run a little fast around here. They like to eat the lights. We need to slow it down."
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Police say several children were transported to the hospital, either with minor injuries or as a precaution.
The company transporting the Delta School students, Total Transportation Corp., declined to comment.
Alina Berrios, owner of Body Reflection on Torresdale Avenue, said, "This is like a third or fourth incident of people going around a school bus and innocent children getting hurt. We need to put a stop to that. We put our trust in school buses to take our kids from home and school. It's unfortunate that this happens."
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