It happened around 8 p.m. near the intersection of Pratt and Charles streets in the city's Frankford section.
According to Philadelphia Chief Inspector Scott Small, the 15-year-old female was walking near the intersection with her friends when they heard gunshots.
At least eight shots were fired. One of the bullets hit the teen's neck.
"We don't believe that this 15-year-old female was an intended target. We believe she was just struck by a stray bullet and grazed to the neck. We don't believe anyone would intentionally shoot a 15-year-old girl walking with her friends," said Small.
No arrests have been made at this time.
Anyone with information is asked to call police at 215-686-TIPS.