It happened around 10 p.m. at the store on the 1800 block of South Street.
Police said approximately 60 young men and women ran into the Walgreens, knocked items from shelves, and then stole merchandise.
The video, released Tuesday, shows some members of the group throwing items at store employees. Police said the employees suffered injuries.
"Oh my goodness!" said neighbor Lauren Felderman.
"I think the neighbors are pretty scared, they're concerned. They would like to see the area get safer, not more dangerous," added Felderman.
Captain Sekou Kinebrew of the Philadelphia Police Department told reporters after the incident that a cashier attempted to intervene and he was hit in a head with a glass bottle.
"Between the things that they stole and the property damaged inside, it's between $6,000 and $7,000 in damage," said Captain Kinebrew.
Before reaching the 1800 block of South Street, teens could be seen on surveillance video stopping traffic, crowding and running along the street.
City Councilman Kenyatta Johnson represents the area.
"I think it was totally unacceptable behavior. I think the young people who are involved and everything that took place inside the store should be held accountable. Most importantly, their parents should be held accountable," said Johnson.
Anyone with information is asked to call police at 215-686-TIPS (8477).