College football betting lines: Oregon an underdog for first time this season as they head to Pen...

ByESPN ESPN logo
Friday, September 26, 2025
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There are four ranked matchups this week across the college football landscape, including the biggest test thus far for No. 6 Oregon and No. 3 Penn State. Oregon entered last year's College Football Playoff as the No. 1 seed before falling in the quarterfinals to Ohio State. Penn State made the semifinals before falling to Notre Dame. Both teams enter this matchup with championship ambitions, and have played up to expectations thus far. ESPN College Gameday will broadcast live from Happy Valley at 12 noon ET.

There are two ranked matches in the SEC, back-to-back on ABC. The No. 4 LSU face No. 13 Ole Miss in Oxford and the No. 17 Alabama take on No. 5 Georgia in Athens immediately after.

The state of Texas has three teams in the top-12 of the AP Poll (No. 9 Texas A&M, No. 10 Texas and No. 12 Texas Tech after their win over Utah) for the first time since 2016, according to ESPN Research.

>Friday, 7 p.m., ESPN

Records: Florida State 3-0, 1-0 vs. AP teams; Virginia 3-1, 0-0 vs. AP teams

>Opening Line: Florida State -7.5, O/U 51.5

>Money line: Florida State (-260); Virginia (+215)

>Over/Under: 60.5 (O EVEN, U 120)

>FPI Projection Florida State by 2.4 points with a 60% probability to win game outright

>Friday, 9 p.m., FOX

Records: TCU 3-0, 0-0 vs. AP teams; Arizona State 3-1, 0-0 vs. AP teams

>Opening Line: Arizona State -1.5, O/U 56.5

>Money line: TCU (+135); Arizona State (-155)

>Over/Under: 54.5 (O -115, U 105)

>FPI Projection Arizona State by 0.1 points with a 51% probability to win game outright

>Saturday, Noon, ESPN

Records: Georgia Tech 4-0, 1-0 vs. AP teams; Wake Forest 2-1, 0-0 vs. AP teams

>Opening Line: Georgia Tech -14.5, O/U 53.5

>Money line: Georgia Tech (-700); Wake Forest (+450)

>Over/Under: 52.5 (O -115, U 105)

>FPI Projection Georgia Tech by 11.6 points with a 84% probability to win game outright

>Saturday, Noon, FOX

Records: USC 4-0, 0-0 vs. AP teams; Illinois 3-1, 0-1 vs. AP teams

>Line Movement Alert: Opened USC -1.5, O/U 56.5

>Money line: USC (-250); Illinois (+210)

>Over/Under: 60.5 (O -115, U 105)

>FPI Projection USC by 6.3 points with a 73% probability to win game outright

>Saturday, Noon, ABC

Records: Notre Dame 1-2, 0-2 vs. AP teams; Arkansas 2-2, 0-1 vs. AP teams

>Opening Line: Notre Dame -6.5, O/U 58.5

>Money line: Notre Dame (-185); Arkansas (+155)

>Over/Under: 63.5 (O -105, U -115)

>FPI Projection Notre Dame by 1.5 points with a 56% probability to win game outright

>Saturday, 12:45 p.m., SEC Network

Records: Utah State 3-1, 0-1 vs. AP teams; Vanderbilt 4-0, 1-0 vs. AP teams

>Opening Line: Vanderbilt -21.5, O/U 59.5

>Money line: Utah State (+1000); Vanderbilt (-2000)

>Over/Under: 58.5 (O EVEN, U -120)

>FPI Projection Vanderbilt by 22.5 points with a 94% probability to win game outright

>Saturday, 3:30 p.m., CBS, Paramount+

Records: Ohio State 3-0, 1-0 vs. AP teams; Washington 3-0, 0-0 vs. AP teams

>Line Opened: Opened Ohio State -10.5, O/U 48.5

>Money line: Ohio State (-320); Washington (+260)

>Over/Under: 51.5 (O -115, U -105)

>FPI Projection Ohio State by 5 points with a 69% probability to win game outright

>Saturday, 3:30 p.m., ABC

Records: LSU 4-0, 1-0 vs. AP teams; Ole Miss 4-0, 0-0 vs. AP teams

>Opening Line: LSU -1.5, O/U 56.5

>Money line: LSU (+105); Ole Miss (-125)

>Over/Under: 57.5 (O -115, U -105)

>FPI Projection Ole Miss by 6.4 points with a 73% probability to win game outright

>Saturday, 3:30 p.m., ESPN

Records: Auburn 3-1, 0-1 vs. AP teams; Texas A&M 3-0, 1-0 vs. AP teams

>Opening Line: Texas A&M -6.5, O/U 46.5

>Money line: Auburn (+195); Texas A&M (-230)

>Over/Under: 52.5 (O -115, U -105)

>FPI Projection Texas A&M by 4.7 points with a 68% probability to win game outright

>Saturday, 3:30 p.m., Peacock

Records: Indiana 4-0, 1-0 vs. AP teams; Iowa 3-1, 0-1 vs. AP teams

>Line Movement Alert: Opened Indiana -3.5, O/U 48.5

>Money line: Indiana (-320); Iowa (+260)

>Over/Under: 48.5 (O -110, U -110)

>FPI Projection Indiana by 8.6 points with a 78% probability to win game outright

>Saturday, 4:15 p.m., SEC Network

Records: Tennessee 3-1, 0-1 vs. AP teams; Mississippi State 4-0, 1-0 vs. AP teams

>Opening Line: Tennessee -9.5, O/U 61.5

>Money line: Tennessee (-280); Mississippi State (+230)

>Over/Under: 62.5 (O -120, U EVEN)

>FPI Projection Tennessee by 6.8 points with a 74% probability to win game outright

>Saturday, 7 p.m., ESPN

Records: Arizona 3-0, 0-0 vs. AP teams; Iowa State 4-0, 1-0 vs. AP teams

>Opening Line: Iowa State -7.5, O/U 49.5

>Money line: Arizona (+175); Iowa State (-210)

>Over/Under: 48.5 (O -110, U -110)

>FPI Projection Iowa State by 2.8 points with a 61% probability to win game outright

>Saturday, 7:30 p.m., NBC, Peacock

Records: Oregon 4-0, 0-0 vs. AP teams; Penn State 3-0, 0-0 vs. AP teams

>Opening Line: Penn State -3.5, O/U 53.5

>Money line: Oregon (+155); Penn State (-185)

>Over/Under: 53.5 (O -105, U -115)

>FPI Projection Penn State by 0.3 points with a 51% probability to win game outright

>Saturday, 7:30 p.m., ABC

Records: Alabama 2-1, 0-0 vs. AP teams; Georgia 3-0, 1-0 vs. AP teams

>Opening Line: Georgia -3.5, O/U 53.5

>Money line: Alabama (+125); Georgia (-145)

>Over/Under: 53.5 (O -105, U -115)

>FPI Projection Georgia by 1.2 points with a 55% probability to win game outright

>Saturday, 7:30 p.m., ESPNU

Records: Massachusetts 0-3, 0-0 vs. AP teams; Missouri 4-0, 0-0 vs. AP teams

>Opening Line: Missouri -43.5, O/U 55.5

>Money line: Off

>Over/Under: 56.5 (O EVEN, U -120)

>FPI Projection Missouri by 44.4 points with a >99% probability to win game outright

>Saturday, 10:15 p.m., ESPN

Records: BYU 3-0, 0-0 vs. AP teams; Colorado 2-2, 0-0 vs. AP teams

>Opening Line: BYU -6.5, O/U 47.5

>Money line: BYU (-260); Colorado (+215)

>Over/Under: 50.5 (O EVEN, U -120)

>FPI Projection BYU by 8.2 points with a 78% probability to win game outright

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