The incident happened around 8:30 a.m. Tuesday on the 1400 block of Wayne Street.
When officers arrived on the scene, Patricia Torres, 44, was found dead from multiple stab wounds, according to Reading police.
The victim's husband, 51-year-old Jose Torres, was arrested and charged with first and third-degree murder.
Investigators say the homicide appears to be the result of a domestic incident.
It's still unclear what sparked the attack.