It happened around 3:55 a.m. Friday on the northbound lanes of 42, by the exit of the Black Horse Pike (9B).
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Police say the driver of a vehicle carrying three people lost control and struck a tree.
Rescue crews responded to the scene and extricated two people from the vehicle.
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One person was pronounced dead at the scene.
Delays were expected around the crash site as police blocked lanes while they continued to investigate.
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