C-Murder, whose real name is Corey Miller, was convicted of shooting a teenager to death in 2002.
A three-judge panel from the state's 5th Circuit Court of Appeal on Wednesday rejected Miller's argument that he didn't get a fair trial.
In 2009, a jury convicted Miller of second-degree murder for shooting 16-year-old Steve Thomas during a confrontation at a nightclub.
Miller claims the judge who presided over his trial allowed jurors to hear prejudicial and unsubstantiated testimony that he threatened witnesses to the shooting. He also accused prosecutors of systematically eliminating black people from the jury.
But the 5th Circuit rejected those arguments.
One of Miller's attorneys didn't immediately return a call seeking comment Thursday.