It happened just before 4:30 a.m. Friday south of Route 30.
Authorities said the truck was traveling northbound on I-295, approaching the White Horse Pike, when it jackknifed.
This created a large fuel spill on the highway.
The tractor-trailer lodged on the concrete median barrier.
Numerous police officers responded to the scene.
The crash shut down left lanes in both directions.
There was no word on injuries.