Hantavirus live updates: US has no cases of Andes hantavirus

The American passenger who tested positive for hantavirus will be transported to the Nebraska Biocontainment Unit, according to Nebraska Medicine, which hosts the facility.

The individual does not have any symptoms and was separated from other passengers during the flight through biocontainment measures. They will be receiving a follow-up test, Nebraska Medicine said.

The remaining passengers will go to the National Quarantine Unit for assessment and monitoring.

The Department of Health and Human Services released a statement on Sunday saying one American has tested positive for hantavirus as the plane with 18 MV Hondius passengers is headed to the U.S.

Two of the passengers on the plane are traveling in the aircraft's biocontainment units "out of an abundance of caution," according to HHS.

The agency said that of the two, one passenger currently has mild symptoms, and the other has tested PCR positive for the virus.

The plane is first going to the ASPR Regional Emerging Special Pathogen Treatment Center (RESPTC) at the University of Nebraska Medical Center before taking the passenger with mild symptoms to a second RESPTC, according to HHS.

"Upon arrival at each facility, each individual will undergo clinical assessment and receive appropriate care and support based on their condition," HHS said.

The plane carrying the 18 Americans who disembarked from the MV Hondius has departed Spain and is heading back to the United States.

The American passengers who disembarked from the MV Hondius have arrived at Tenerife airport in the Canary Islands.

A total 18 people will be on the American repatriation flight, including the 17 Americans and one British national who is a resident of the U.S., the Spanish minister of health told ABC News.

-ABC News' Maggie Rulli