Shots rang out on the 3200 block of Tampa Street in the city's Kensington section shortly after midnight Tuesday.
Officers arrived to find a Hispanic man suffering multiple gunshot wounds to his head, face and chest.
He was pronounced dead at the scene.
"There are cameras in the area. Hopefully, it was captured on these cameras," said Capt. Tom Davidson.
There are no suspects and police have not determined a motive at this time.
Anyone with information is asked to contact the homicide unit at 215-686-3334 or call 911. As with all unsolved homicides in Philadelphia, there is a $20,000 reward for information leading to an arrest and conviction.
Philadelphia recorded 351 murders in 2018, the most in 11 years.
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