Saturday's march is among dozens of rallies being held around the country. The activists are hoping to create an enduring political movement that will elect more women to government office.
Many marchers wore pink cat-ear hats as a show of solidarity, while others carried signs stating opposition to President Donald Trump and his policies.
The rallies come a year after women rallied in cities across the Northwest and the United States, many saying they hoped to send a message to Trump about equality and other causes.
Afterward, a wave of women decided to run for elected office and the #MeToo movement against sexual misconduct became a cultural phenomenon.
Today, they marched down the Ben Franklin Parkway, their messages were written on signs and on musical instruments.
There were even 3-D creations - like a basket of Deplorables.
Demonstrator Patty Shuminski said, "I tried to do a poster but I couldn't fit every thought on a poster, there's too many. So I decided to just go with the characters that are now running our government."
The march drew people concerned about many issues.
Lou Ann Merkle of Plymouth Meeting said, "The concept that they don't believe there's climate change when there actually is."
Gloria Miller of Mount Laurel, NJ added, "I march for my students. They are special education. They are white, they are black, they are special, and they are amazing."
Katarina Loedel of Downingtown, Pa. said, "I believe that children and humans have the right to have an education here, have the right to live here. No human being is illegal."
Organizers say the focus of this year's march is the upcoming elections.
Emily Cooper Morse, Philly Women's March Lead Organizer said, "We really want people to get out and vote. We have people here that are able to register people to vote today and we really want to get people ready for the primaries in May and the midterms in November."
The march ended with a rally in front of the Philadelphia Museum of Art.
But the demonstrators were not all women.
Kyle Park of Morrisville, Pa. wanted to come up here to support his mommy, his grandmommy, his aunts and everybody else.
And the signs were not all political. Kyle's sign read "resists naps."
He's not napping for us too well right now. That's the only thing he really understands.
National organizers will hold the main march in Las Vegas tomorrow.
After the deadly shootings there last year, they say Nevada will be a battleground state for the Senate in the 2018 elections.
(ASSOCIATED PRESS CONTRIBUTED TO THIS REPORT)
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