Home openers were announced earlier in the day, with a few early games standing out among the bunch.
Read More:NFL 2022 schedule analysis: Easiest, hardest fantasy football opponents and more
This year's action will begin right where it ended -- at Sofi Stadium in Inglewood, California. The Buffalo Bills face the Los Angeles Rams. It should make for an interesting matchup for Von Miller, who signed a six-year contract with Buffalo after being a member of the Rams' Super Bowl-winning squad.
The first Monday night game of the year will feature the Denver Broncos against the Seattle Seahawks at CenturyLink Stadium, meaning Russell Wilson won't wait long to return to Seattle.
As always, several teams celebrated schedule release day with particularly creative posts to announce their upcoming opponents. Some may be more imaginative than others, but we'll let you be the judge.
Lions release schedule with hilarious self-defense training video
The Lions get an assist from viral self-defense trainer Dale Brown to reveal their schedule.