I-76 westbound will be shut down between 9 p.m. and 5 a.m., between 30th Street and the Vine Street Expressway.
On the Green Lane Bridge in Manayunk, drivers were seen carefully maneuvering around damaged pavement.
A stretch of Route 202 northbound in Upper Merion Township opened Tuesday after nine months of sinkhole repairs.
Authorities say residents and businesses in the area may experience water service disruptions because of the break.
The bridge closed to cars in 2021 after inspections revealed it was deteriorating.
Pedestrians and bicyclists will have the Martin Luther King, Jr. Drive Bridge all to themselves this weekend and then drivers will once again get to use the bridge starting Monday morning.