It happened around 6 a.m. Saturday at North 29th and Diamond streets in Strawberry Mansion.
Police said the bus collided with another vehicle.
The impact sent the bus careening into to six to eight other cars parked near the intersection.
There were four passengers on the SEPTA bus at the time of the crash.
The bus driver, the passengers, and the driver of the other vehicle were taken to the hospital.
Their conditions have not been released.
The cause of the crash is under investigation.