It happened around 7:10 p.m. on the 5800 block of Walton Avenue.
Police say 22-year-old Shoni Sanders was shot once in her chest upon opening the door by an unknown man.
She was rushed to the hospital where she later died.
Acting Philadelphia Police Commissioner Christine Coulter said Sanders appeared to have been the intended target.
Police say there was another woman and children at the home when the shooting occurred.
No description of the shooter is available at this time.
Anyone with any information is asked to call 215-686-TIPS.