It happened around 9:30 p.m. Thursday in the 200 block of West Glenwood Avenue in the Fairhill section of the city.
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Police say the victim was shot in the chest.
She was taken to Temple University Hospital where she died of her injuries.
A 23-year-old man was also shot during the incident, police say.
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He remains hospitalized in critical condition.
Police say the grandmother and a 4-month-old child in the house escaped unharmed.
Authorities believe the home was targeted. There is no information on a suspect.
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