The truck carrying paper products went over an embankment and ended up about 100 feet down the side of the road.
The accident happened just before 6 a.m. along the ramp from southbound I-495 to northbound I-295.
The driver was trapped in the truck for about an hour. There's no word on the severity of any injuries.
Drivers faced a long line of traffic as they headed south on I-495.