The representative said Duke died Monday night in Los Angeles. He was being treated for chronic lymphocytic leukemia.
During his 40-year-plus career, Duke appeared on a number of Frank Zappa's albums and played in the Don Ellis Orchestra and Cannonball Adderley's band. He played keyboard on Michael Jackson's multiplatinum 1979 album, "Off the Wall," and was a producer for Miles Davis, Smokey Robinson, Gladys Knight, Dionne Warwick and Natalie Cole.
He also released more than 30 solo albums.
Duke's wife, Corine, died from cancer last year.