But he'll be out of town on May 10 - still orbiting the globe on the International Space Station.
So UConn has arranged for the 54-year-old astronaut to tape the speech in space.
His recorded address will be shown to more than 400 graduating seniors and their families on video.
Mastracchio earned a bachelor's degree in electrical engineering and computer engineering from UConn in 1982. He'll receive an honorary doctorate.
The Waterbury native returns to earth from his eight-month mission and fourth trip into space on May 13.
