It happened around 3:40 a.m. Thursday on the 4900 block of Hoopes Street.
Police say a woman was shot dead inside a house.
A man was struck by three bullets and taken to the hospital in critical condition. He was pronounced dead shortly before 5:30 a.m.
Investigators don't have a motive.
They are questioning other people found inside the boarded-up building. Authorities described the building as a known drug house.