The shooting happened at a birthday party on Delafield Street in New Brunswick, New Jersey.
Police say someone started shouting and interrupted the off-campus party.
Authorities are looking for four gunmen who opened fire and struck individuals who were present.
Police found eight people suffering from apparent gunshot wounds. The injured were transported to an area hospital where two male victims were pronounced dead -- including the person celebrating his birthday.
Surveillance video captured the violence as a car pulled up and the four suspects jumped out with their guns drawn.
Some in the area ducked for cover while others ran for their lives.
It took just a few seconds, and when the bullets stopped flying, several dozen shell casings were left on the street.
Thus far, the investigation has determined that there is no affiliation with Rutgers University or its students. According to the Associated Press, the area is known for student housing and accompanying parties.
While many students do live on the same street, no students were hurt or involved.
"I ran up to one young man and I'm saying 'I'm here man,' and he's gargling blood, so I flipped him over so he won't choke or suffocate, checked for a pulse," witness and Rutgers junior Jacob Beacher said.
Witnesses told WABC-TV that there was another problem before the shooting, a fight happened at the very same house.
The New Brunswick Police Department is actively investigating this incident and asks that anyone with information, or who may have been in the area at the time, contact the NBPD's Detective Bureau at 732-745-5217.
-- The Associated Press contributed to this report.