The Kardashian family patriarch and Olympic gold medalist wasn't hurt, but seven people were taken to the hospital for evaluation after the crash that happened shortly after noon on Pacific Coast Highway in Malibu, said Los Angeles County sheriff's Sgt. Philip Brooks.
The moment of impact was captured by celebrity photographers who quickly posted the images on the Internet, but Philips said there was no evidence Jenner was trying to get away from them.
"PCH is a straight road. There's no place to go to evade," Brooks said. "Being a celebrity, he's often followed by the paparazzi and he's aware of that. He was on his way home, and they happen to know his route."
Brooks said Jenner cooperated with investigators, passed a field sobriety test and voluntarily submitted a blood sample to determine whether he was intoxicated.
"He did not appear intoxicated or under the influence of anything at the time," Brooks said.
Jenner was going north when his black Cadillac Escalade rear-ended a Lexus sedan that had just struck the back of a black Toyota Prius, Brooks said. The Lexus veered into oncoming traffic in a southbound lane and collided head-on with a black Hummer.
The driver of the Lexus -- a woman in her 70s -- was pronounced dead at the scene.
Photos of the crash site showed the white Lexus mangled in the front and back, facing the Hummer, which had a heavily damaged engine and its hood popped open. Jenner's Escalade, which was pulling an off-road vehicle, had a damaged front end.
The crash occurred about a mile west of Pepperdine University, on a stretch of road sandwiched between the beach and the Santa Monica Mountains.
Jenner, 65, won a gold medal in the men's decathlon at the 1976 Summer Games, but he is best known to a younger generation as Kim Kardashian's stepfather. He and Kris Jenner frequently appeared on the reality series "Keeping Up with the Kardashians" along with their children, and the pair's relationship and its troubles have been featured prominently on the show.
The two finalized their divorce late last year, ending 23 years of marriage.
The Associated Press contributed to this report.
Bruce Jenner Unhurt In Fatal Crash
Sargeant Philip Brooks of the Malibu-Lost Hills Sheriff Station comments on the recent car accident that involved former Olympian Bruce Jenner.