The Hall of Fame receiver and Cowboys "Triplet" said that after his former team beat the New Orleans Saints in November, he "was so elated and hyped I lost my voice and the problem persisted for almost (two) months."
That prompted him to consult various throat specialists, who recommended a biopsy.
Irvin, 53, noted in the post that his father died of throat cancer at the age of 51.
A three-time Super Bowl champion, Irvin's playing career was cut short in 1999 by a spinal cord injury.
He was inducted into the Pro Football Hall of Fame in 2007 and is currently an analyst for NFL Network.