It happened before 8 a.m. Wednesday on Route 70 at Eayerstown Road.
Video from Chopper 6 showed two sedans, one with front-end damage, the other with rear-end damage, in the middle of the intersection.
Police say a vehicle driven by George Holmberg hit a Ford Mustang as it waited to turn onto the road.
The impacts spun the Mustang into oncoming traffic where it was hit again by a Toyota Camry.
Both the drivers of the Mustang and the Camry were seriously hurt.
Holmberg was charged with careless driving.
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