Betty Wright, 58, of Roosevelt, N.Y., died in the three-vehicle crash on Interstate 80 in Greene Township, state police said.
The driver of the wrong-way car, John Pick, 44, of Lewisburg, also died, police said.
Timothy Wright has released more than a dozen gospel recordings, and his latest album, "Jesus, Jesus, Jesus," came out last year. He is the pastor at Grace Tabernacle Christian Center in New York City.
The Wrights were returning from a Church of God in Christ conference in Detroit, said Leroy Johnson, a trustee at Grace Tabernacle.
The couple have five sons, and the family asked that no other information be released, Johnson said Saturday.
A passenger in the third vehicle is in fair condition, said Geisinger spokesman Thomas Schaeffer.
