States including New Jersey, Ohio and Maryland already permit it. Pennsylvania officials say the State Athletic Commission expects to regulate four to five events per month.
The commission worked for more than a year on the sport's regulations.
Promoters and fighters must be licensed and insured. Fighters also must take a pre-fight physical exam by a commission-approved doctor while emergency personnel must be at ringside at all times.
Ultimate Fighting Championship is the biggest name in mixed martial arts.
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