It happened around 11:15 p.m. in the 2000 block of East Orleans Street in the Port Richmond section of Philadelphia.
Police arrived to find a 29-year-old man with multiple stab wounds. He was rushed to Temple Hospital, but was pronounced dead a short time later.
A second man with a slash wound was also found at the scene.
Police say it appears both men were in a fight stemming from a domestic issue.
The investigation in this case continues.