Rescuers were called to the scene around 7:45 a.m. in the 200 block of Route 50 near 3rd Avenue, where they found heavy smoke and fire coming from the home.
Firefighters went inside to search for victims, and found 79-year-old Anna Cristinzio dead.
Investigators say she was the only occupant of the house.
Two firefighters were transported to Atlantic Care Regional Medical Center for non-life threatening issues.
The cause of the fire remains under investigation at this time.