A spokeswoman for the 40-year-old TV personality says Harrison and his wife are ending their 18-year marriage.
Harrison has hosted the ABC dating series and its various spin-off since it debuted in 2002.
Harrison and his wife, Gwen, said in a statement that despite their "incredibly difficult decision to separate," their love and mutual respect remain, and they look forward to sharing in the lives of their two children.
The eighth season of "The Bachelorette" is set to premiere May 14.
