It happened around 7:00 Saturday morning near the intersection of Castor and Aramingo avenues.
Police say that an 11-year-old and a 21-year-old were struck by an SUV. The driver of the vehicle did not stop at the scene.
Both victims were taken to an area hospital in critical condition.
The striking vehicle is described as a dark grey BMW, SUV x5 Model E70. It was last seen driving westbound on Castor Avenue.
Anyone with information is asked to contact Philadelphia Police.