The accident happened around 5:00 p.m. on Eayrestown Road and Muncipal Drive.
According to accident investigators, 19-year-old Samantha Lucas of Southampton, New Jersey was driving southbound on Eayrestown Road when her vehicle collided with the school bus in the northbound lane.
Lucas was airlifted to Cooper Trauma Center in Camden where she later died.
The driver of the bus is identified as Damir Marjanovic, 49, of Westampton, New Jersey. She and an aide, who was onboard the bus at the time of the crash, were transported to Virtua Memorial Hospital where they were treated and released.
Police are asking anyone who may have witnessed the crash to call the Lumberton Police at 609-267-1111 or 609-267-8300.